THE KINETIC PHASE 2 RANDOMIZED CONTROLLED TRIAL OF ORAL PAMAPIMOD-PIOGLITAZONE IN NON-CRITICALLY ILL COVID-19 INPATIENTS

The KINETIC phase 2 randomized controlled trial of oral pamapimod-pioglitazone in non-critically ill COVID-19 inpatients

Summary: The simply southern cat shirt combination of pamapimod and pioglitazone (KIN001) has a synergetic antiviral, anti-inflammatory, and antifibrotic activity, which may prevent evolution toward COVID-19-associated severe respiratory failure.In a randomized, placebo-controlled, double-blind, phase 2, multicenter trial, 128 non-critically ill ho

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Optimization design of horizontal well fracture stage placement in shale gas reservoirs based on an efficient variable-fidelity surrogate model and intelligent algorithm

Hydraulic fracturing technique increases shale gas well productivity significantly.Horizontal well fracture optimization has been studied by many researchers worldwide in the past decade.However, most of these researches relied on computationally expensive numerical simulation models for objectives evaluation during the optimization process.This af

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Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments

Peipei Cao,1 Hao Zhang,2 Huiling Meng,1 Yajia Cheng,1 Haiqi Xu,3 Siwen Zang,1 Zongjin Li,1 Jianlin Cui,1,4 Yuhao Li1,5 1Nankai University School of Medicine, Tianjin, People’s Republic of China; 2Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 3Faculty of Life Science, Univer

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